TMOD-04. CHARACTERIZATION OF MUTANT IDH1 OLIGODENDROGLIOMAS
نویسندگان
چکیده
منابع مشابه
Mutant IDH1 is required for IDH1 mutated tumor cell growth
Frequent somatic hotspot mutations in isocitrate dehydrogenase 1 (IDH1) have been identified in gliomas, acute myeloid leukemias, chondrosarcomas, and other cancers, providing a likely avenue for targeted cancer therapy. However, whether mutant IDH1 protein is required for maintaining IDH1 mutated tumor cell growth remains unknown. Here, using a genetically engineered inducible system, we repor...
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Oncogenic IDH1 and IDH2 mutations contribute to cancer via production of R-2-hydroxyglutarate (2-HG). Here, we characterize two structurally distinct mutant- and isoform-selective IDH1 inhibitors that inhibit 2-HG production. Both bind to an allosteric pocket on IDH1, yet shape it differently, highlighting the plasticity of this site. Oncogenic IDH1R132H mutation destabilizes an IDH1 "regulator...
متن کاملMetabolic Reprogramming in Mutant IDH1 Glioma Cells
BACKGROUND Mutations in isocitrate dehydrogenase (IDH) 1 have been reported in over 70% of low-grade gliomas and secondary glioblastomas. IDH1 is the enzyme that catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate while mutant IDH1 catalyzes the conversion of α-ketoglutarate into 2-hydroxyglutarate. These mutations are associated with the accumulation of 2-hydroxyglutarate ...
متن کاملEpigenetic landscape in IDH1 mutant glioma
A1 Investigations of the functional interactions between CIC and ATXN1L in Oligodendroglioma D. Wong, V. Leblanc, S. Chittaranjan, M. Marra, S. Yip BC Cancer Agency, UBC, Vancouver, BC, Canada doi:10.1017/cjn.2017.2 Oligodendroglioma (ODG) is a subtype of low grade glioma marked by unique clinical and genomic characteristics including slow predictable progression, IDH mutation, and 1p19qcodelet...
متن کاملIDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas.
IDH1 encodes isocitrate dehydrogenase 1, which participates in the citric acid cycle and was recently reported to be mutated in 12% of glioblastomas. We assessed IDH1 mutations in 321 gliomas of various histological types and biological behaviors. A total of 130 IDH1 mutations was detected, and all were located at amino acid residue 132. Of these, 91% were G-->A mutations (Arg-->His). IDH1 muta...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2019
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/noz175.1103